In the autumn of 2010, WHO official Eiko Kobayashi (Rei Dan Rei Dan (played by Satoshi Tsubuki), a high fever patient admitted to a municipal hospital in Tokyo. After being admitted to the hospital, his condition took a turn for the worse and he coughed up blood and died. The patient's family and some doctors also fell ill due to the infection. At the same time, the bird flu virus was detected in a chicken farm in the suburbs, and the peaceful life of the owner Kami So and his daughter (played by Chizuru Ikewaki) was broken.
Kobayashi Eiko was ordered to guide the epidemic prevention, and his old acquaintance Matsuoka served as his assistant. The epidemic spread rapidly, with the death toll reaching 2,000 within a month. Panic broke out in various places and attracted international attention. The government quickly sealed off the affected areas. Matsuoka accidentally learned that the source of the virus might be elsewhere. The test results returned from abroad supported his judgment, and Matsuoka decided to go abroad to find the source of the disease. In the unprecedented epidemic, each of Matsuoka, Xiaolin and Shen Cang will face the test of their own choice.
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