Susan Murphy (Reese Witherspoon), a beautiful girl living in a small town in California (voiced by Paul Rudd) is about to get married to his beloved boyfriend Derek Dirt (voiced by Paul Rudd). But at this critical moment, she was hit on the head by a meteorite, and then her whole body glowed and turned into a tall giant with white hair. Her transformation scared away her friends and family, and she was captured and imprisoned by a mysterious group of heavily armed men. Susan was taken to the secret base of Area 52 by the military, and monsters from all corners of the earth became the subject of research by scientists. At the same time, a UFO harboring evil power is approaching the Earth at an extremely high speed, and the alien it brings, Galeksaha (voiced by Rainn Wilson), threatens to destroy the Earth and destroy mankind. The humans resisted, but their weapons were defeated by Galak Sahar. The earth is in danger, and people place their fate on Susan and her monster friends...
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