The Muppets kembali dalam komedi baru, Muppets from Space. The Muppets memulakan pengembaraan terestrial tambahan yang lucu dengan harapan untuk mengetahui ahli keluarga Gonzo adalah makhluk asing dari planet yang jauh! Gonzo kemudian mendapat mesej bahawa saudara-maranya akan datang untuk melawat, dari angkasa lepas! Tetapi apabila berita tersebar di rancangan bual bicara Miss Piggy, UFO Mania, bahawa makhluk asing yang mesra akan datang,

The Muppets are back in a new zany comedy, Muppets from Space. The Muppets embark on a hilarious extra terrestrial adventure in hopes of finding out about Gonzo's family members are aliens from a distant planet! Gonzo then gets a message that his relatives are coming for a visit, from outer space! But when word gets out on Miss Piggy's talk show, UFO Mania, that the friendly aliens are coming, a secret government agency led by K. Edgar Singer (Jeffrey Tambor) captures Gonzo and goes to great lengths to learn when his extra-terrestrial family will arrive. Now only the Muppets, led by Kermit and Miss Piggy, can save Gonzo and make the world safe for a friendly alien invasion!